Dermal fillers are used to diminish facial lines, lift and smooth out shadows and contours, and restore the lost volume to the face, turning back the hands of time. Fillers such as Restylane, Restylane Refyne/Defyne, Juvederm, Voluma/Vollure/Volbella and Versa are composed of hyaluronic acid, a natural component found in the skin. Hyaluronic acid acts as a humectant, attracting up to 1000 times its weight in water. Non-hyaluronic acid fillers such as Sculptra, Bellafill, and Radiesse are bio-stimulatory fillers because these products stimulate the skin to produce its own collagen, which can result in a longer lasting cosmetic result. The best dermal filler depends on the person’s needs, budget, lifestyle and desired duration of result.